H2N2V1, Main, Exploration, bibRecord, 000F71

Can human viruses infect porcine xenografts?

Identifieur interne : 000F71 ( Main/Exploration ); précédent : 000F70; suivant : 000F72

Can human viruses infect porcine xenografts?

Auteurs : Anne Laure Millard [Suisse] ; Nicolas J. Mueller [Suisse]

Source :

Xenotransplantation [ 0908-665X ] ; 2010-01.

RBID : ISTEX:AF34C4D6C09A1509B5868737E9E511898538AED8

English descriptors

Teeft :
- Adenovirus, Biochem biophys, Cell cultures, Cellular machinery, Chronic hepatitis, Clinical trials, Cytomegalovirus, Defective entry, Gnotobiotic pigs, Graft function, Hepatitis, Herpes simplex virus, Herpesviruses, Hospital epidemiology, Human cells, Human cytomegalovirus, Human noroviruses, Human pathogens, Human viruses, Immune suppression, Immunosuppressed patients, Infant pigs, Infection, Infectious diseases, Infective progeny, Islet, Mueller, Nipah, Nipah virus, Pathogen, Permanent porcine cell lines, Porcine, Porcine cell lines, Porcine cells, Porcine islets, Porcine lung epithelial cells, Porcine origin, Porcine tissues, Porcine xenograft, Porcine xenografts, Productive infection, Receptor, Replication, Respiratory tract, Transplantation, University hospital zurich, Unknown pathogens, Unpredictable consequences, Viral, Viral proteins, Viral strains, Virol, Virus, Virus infection, Xenograft, Xenograft infection, Xenotransplantation.

Abstract

Millard AL, Mueller NJ. Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6–10. © 2010 John Wiley & Sons A/S. Abstract: Xenotransplantation exposes the recipient to known and unknown pathogens of the donor pig (donor‐derived xenosis). A major effort has been undertaken to minimize the risk of transmission from the donor using specialized breeding techniques. With the exception of endogenous retroviruses and porcine lymphotropic herpesvirus, exclusion of known pathogens was successful and has eliminated a majority of donor pathogens. In the recipient, enhanced replication of many pathogens will be stimulated by the immune responses induced by transplantation and by the immune suppression used to prevent graft rejection. Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. This review focuses on human or recipient‐derived pathogens and their potential harmful role in xenograft infection.

Url:

https://api.istex.fr/ark:/67375/WNG-7RVNHJS4-X/fulltext.pdf

DOI: 10.1111/j.1399-3089.2009.00566.x

Affiliations:

Suisse

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Le document en format XML

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<term>Infectious diseases</term>
<term>Infective progeny</term>
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<term>Porcine lung epithelial cells</term>
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<term>Virol</term>
<term>Virus</term>
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<term>Xenograft infection</term>
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<front><div type="abstract" xml:lang="en">Millard AL, Mueller NJ. Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6–10. © 2010 John Wiley & Sons A/S. Abstract:  Xenotransplantation exposes the recipient to known and unknown pathogens of the donor pig (donor‐derived xenosis). A major effort has been undertaken to minimize the risk of transmission from the donor using specialized breeding techniques. With the exception of endogenous retroviruses and porcine lymphotropic herpesvirus, exclusion of known pathogens was successful and has eliminated a majority of donor pathogens. In the recipient, enhanced replication of many pathogens will be stimulated by the immune responses induced by transplantation and by the immune suppression used to prevent graft rejection. Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. This review focuses on human or recipient‐derived pathogens and their potential harmful role in xenograft infection.</div>
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Can human viruses infect porcine xenografts?

Can human viruses infect porcine xenografts?

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri